Calcium in order to Phosphorus Proportion, PTH, and you may Bones Health

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Estimates by the Beam Peat, PhD: “This new proportion out of calcium supplements to help you phosphate is essential; for this reason whole milk and you may mozzarella cheese are very worthwhile for losing weight, or for stopping putting on weight. If you commonly most active, zero fat whole milk and you will mozzarella cheese work better, because the body fat fat are not called for.”

“The foodstuffs highest inside the phosphate, in line with calcium supplements, are cereals, beans, chicken, and you can seafood. Of a lot wishing products contain additional phosphate. Edibles with increased, safe proportion off calcium supplements so you can phosphate is actually leaves, for example kale, turnip vegetables, and you will beet greens, and some fresh fruit, dairy, and parmesan cheese.”

Br J Nutr

“100 % free unsaturated efas stimulate the pressure hormone, and you will cortisol stops oxidization regarding sugar and you will turns it into the oily acids and you will triglycerides. Staying cortisol and you may worry reduced ‘s the main matter. Remaining a leading ratio of calcium to help you phosphate helps you to oppose the pressure k-calorie burning.” “Previous publication try proving you to definitely continuously phosphate increases pain, tissues atrophy, calcification regarding blood vessels, cancer tumors, alzhiemer’s disease, and, in general, the processes regarding aging.”

2006 September;96(3):545-52. High phosphorus intakes very and negatively affect Ca and bones metabolic process during the a serving-founded trend inside the fit younger ladies. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. Ca and you can P is actually each other essential nutrients to own limbs consequently they are known to connect with probably one of the most extremely important regulators of limbs metabolism, parathyroid hormonal (PTH). As well generous good P intake, normal out-of Western diet, was deleterious to bone from improved PTH secretion. Couple managed amount-reaction scientific studies are on the consequences out-of large P consumption inside the man. I learned this new small-name ramifications of five P doses into the Ca and you may bones k-calorie burning inside the 14 compliment women, 20-twenty eight yrs old, who were randomized in order to four regulated analysis days; thus for every research subject supported because her very own handle. P supplement dosages out of 0 (placebo), 250, 750 otherwise 1500 mg was drawn, put into about three doses within the investigation go out. The dishes served was the exact same during each study go out and you can offered 495 mg P and you may 250 mg California. The latest P dosages influenced the fresh serum PTH (S-PTH) for the an amount-established fashion (P=0.0005). Discover a reduction in gel ionized Ca quantity only for the the greatest P serving (P=0.004). The new marker away from bones formation, bone-certain alkaline phosphatase, reduced (P=0.05) additionally the limbs resorption marker, N-terminal telopeptide from collagen types of I, increased responding with the P dosage (P=0.05). Which regulated dosage-impulse analysis indicated that P have a dose-dependent affect S-PTH and you can expands PTH hormonal rather whenever Ca consumption are lowest. Excessively highest P intake adversely has an effect on bone k-calorie burning from the decreasing limbs creation and you can broadening bone resorption, since the expressed by bones metabolic rate markers.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.

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