Calcium supplements so you can Phosphorus Proportion, PTH, and you can Limbs Wellness

Kemi VE, Karkkainen MU, Karp HJ, Laitinen KA, Lamberg-Allardt CJ

Quotes by the Beam Peat, PhD: “Brand new ratio out of calcium supplements in order to phosphate is very important; that’s why whole milk and cheese are so beneficial for weight loss, and blocking gaining weight. For individuals who are not very active, low fat dairy and you may mozzarella cheese operate better, due to the fact excess fat calories are not required.”

“The meals high in the phosphate, relative to calcium supplements, is grain, beans, beef, and seafood. Of many prepared ingredients consist of added phosphate. Ingredients with a top, safe ratio from calcium supplements so you can phosphate is makes, instance kale, turnip veggies, and you may beet greens, and lots of good fresh fruit, dairy, and parmesan cheese.”

Br J Nutr

“100 % free unsaturated essential fatty acids stimulate the stress hormone, and you will cortisol reduces oxidization from sugar and you will transforms they into the fatty acids and triglycerides. Remaining cortisol and you may stress reduced ‘s the main procedure. Remaining a top ratio regarding calcium so you can phosphate helps you to contradict pressure metabolism.” “Recent book are exhibiting that way too much phosphate increases pain, cells atrophy, calcification off bloodstream, disease, dementia, and you may, generally, the new process from ageing.”

2006 Sep;96(3):545-52. High phosphorus intakes exceptionally and you may negatively connect with Ca and you may bone k-calorie burning when you look at the a dose-oriented style from inside the healthy younger women. Kemi VE, Karkkainen MU, Lamberg-Allardt CJ. Ca and you can P was each other essential nutrients having bones consequently they are known to apply at one of the most very important bodies out of limbs metabolism, parathyroid hormone (PTH). Too good a beneficial P consumption, regular out-of West dieting, could be deleterious in order to limbs from increased PTH secretion. Couple regulated dose-effect research is on the consequences out-of highest P consumption during the son. We read the fresh new small-title effects of four P dosage on Ca and you can bones metabolism within the fourteen compliment lady, 20-twenty-eight years of age, who had been randomized to help you five regulated research days; therefore each analysis topic served as her own manage. P complement doses out of 0 (placebo), 250, 750 otherwise 1500 milligrams was indeed drawn, split up into about three amounts inside data big date. The meals served was in fact alike during the for every data day and you may considering 495 milligrams P and 250 mg Ca. The fresh new P doses influenced the fresh solution PTH (S-PTH) when you look at the a serving-based fashion (P=0.0005). There is a decrease in gel ionized Ca North Charleston escort service concentration simply during the the greatest P dose (P=0.004). Brand new marker out of limbs creation, bone-specific alkaline phosphatase, diminished (P=0.05) and the limbs resorption marker, N-critical telopeptide from collagen types of I, increased in response on the P amounts (P=0.05). It controlled dosage-impulse research indicated that P features an amount-depending affect S-PTH and you will expands PTH secretion significantly whenever California intake try low. Very highest P consumption negatively impacts bone metabolism by the coming down bone creation and you may increasing limbs resorption, once the conveyed by the bones k-calorie burning markers.

20 Oct 1. Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females. A high dietary P intake is suggested to have negative effects on bone through increased parathyroid hormone secretion, as high serum parathyroid hormone (S-PTH) concentration increases bone resorption. In many countries the P intake is 2- to 3-fold above dietary guidelines, whereas Ca intake is too low. This combination may not be optimal for bone health. In a previous controlled study, we found that dietary P dose-dependently increased S-PTH and bone resorption and decreased bone formation. The aim of the present study was to investigate the dose-response effects of Ca intake on Ca and bone metabolism with a dietary P intake higher than recommended. Each of the twelve healthy female subjects aged 21-40 years attended three 24-h study sessions, which were randomized with regard to a Ca dose of 0 (control day), 600 or 1200 mg, and each subject served as her own control. The meals on each study day provided 1850 mg P and 480 mg Ca. S-PTH concentration decreased (P < 0.001) and serum ionized Ca concentration increased (P < 0.001) with increasing Ca doses. The bone formation marker, serum bone-specific alkaline phosphatase, did not differ significantly (P = 0.4). By contrast, the bone resorption marker, urinary N-terminal telopeptide of collagen type I, decreased significantly with both Ca doses (P = 0.008). When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive.

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